| Gene Symbol | HSP40PROTEIN |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 80 kDa |
| Amino Acids | 70 aa |
| GeneCards | HSP40PROTEIN |
| Human Protein Atlas | HSP40PROTEIN |
| J-domain | ~70 amino acids, mediates interaction with Hsp70 |
| G/F-rich region | Glycine-phenylalanine rich flexible linker |
| C-terminal substrate-binding domain | Variable, determines specificity |
| Alzheimer's disease | DNAJC family members reduce Aβ aggregation |
| Parkinson's disease | DNAJC proteins prevent alpha-synuclein aggregation |
| ALS | Modulate mutant SOD1 and FUS aggregation |
| Huntington's disease | DNAJC proteins assist mutant huntingtin clearance |
| Associated Diseases | ALS, dementia, disease, frontotemporal, neurodegeneration, Neurodegenerative Diseases |
| Interactions | AMYLOID, APOE4, ATP, BAG1, DNAJA1, DNAJB1 |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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