| Gene Symbol | GDNF |
| Aliases | Glial Cell Line-Derived Neurotrophic Factor |
| Protein Family | GDNF family (TGF-β superfamily) |
| Function | Maintains tyrosine hydroxylase expression |
| Primary Expression | Secreted, Extracellular space |
| Subcellular Localization | Secreted, Extracellular space |
| Molecular Weight | 15 kDa |
| Pathways | PI3K, MAPK, TGF-β |
| UniProt ID | P39905 |
| GeneCards | GDNF |
| Human Protein Atlas | GDNF |
| Signal peptide | For secretion |
| Mature domain | Active form that binds receptors |
| Dimerization domain | Forms functional homodimers |
| PI3K/Akt pathway | Promotes neuronal survival |
| Associated Diseases | Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety, CYTOKINES |
| Known Drugs/Compounds | levodopa, rapamycin, trehalose |
| Interactions | ACLY, ADCY3, AKT, ALOX15, ALPHA-SYNUCLEIN, ALZHEIMER |
| SciDEX Hypotheses | GDNF Gradient Establishment by Schwann Cells Enabl |
| KG Connections | 733 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!