| Gene Symbol | GABRB2 |
| Full Name | Gamma-aminobutyric acid type A receptor beta2 subunit |
| Aliases | GABA-A Receptor Beta 2 |
| Chromosome | 5q34 |
| Function | GABRB2 encodes the beta 2 subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system. |
| Subcellular Localization | </b></td><td>Plasma Membrane (Neuronal)</td></tr> |
| Molecular Weight | 54 kDa |
| UniProt ID | [P47870](https://www.uniprot.org/uniprot/P47870) |
| Ensembl ID | ENSG00000145888 |
| OMIM | 137140 |
| GeneCards | GABRB2 |
| Human Protein Atlas | GABRB2 |
| Extracellular N-terminal domain | Contains the GABA binding site at alpha-beta subunit interfaces |
| Transmembrane domain | Four helices (M1-M4) form the ion channel pore |
| Intracellular loop | Between M3 and M4, contains phosphorylation sites and trafficking motifs |
| Associated Diseases | ALS, Alzheimer, Autism, Bipolar, Cancer, Inflammation |
| Interactions | CACNA1B, CACNA1H, DRD1, DRD2, GABRA1, GABRB3 |
| KG Connections | 75 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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