gene

GABRB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
7Outgoing
7Incoming
0Experiments
0Debates

Summary

GABA-A receptor beta3 subunit - critical inhibitory receptor in neurological disease

View on Wiki →

No AI portrait yet

🧬 Gene Info
Gene SymbolGABRB3
AliasesGABA-A receptor beta3 subunit
Chromosome15q12
Protein TypeReceptor
Functionis a critical component of many GABA-A receptor subtypes, including the predominant benzodiazepine-sensitive receptors in the thalamus and cortex.
Primary ExpressionBrain (thalamus, cortex, hippocampus), widespread CNS
Molecular Weight54 kDa
Amino Acids473 aa
UniProt IDP28472
OMIM137192
GeneCardsGABRB3
Human Protein AtlasGABRB3
Associated Diseasesneurodegeneration
InteractionsA2M, BCHE, CHRFAM7A, CNTN1, DNA, ESR1
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: GABRB3 — AlphaFold P28472 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

GABRB3 Gene

gene · 1921 words

GABRB3-Related Epilepsy

disease · 1072 words

GABRB3

gene · 1004 words

GABRB3 Protein - GABA-A Receptor Beta 3 Subunit

protein · 666 words

Pathway Diagram

flowchart TD
    N0["GABRB3"]
    N1["A2M"]
    N1 -->|"interacts with"| N0
    N2["BCHE"]
    N2 -->|"interacts with"| N0
    N3["CHRFAM7A"]
    N3 -->|"interacts with"| N0
    N4["CNTN1"]
    N4 -->|"interacts with"| N0
    N5["ESR1"]
    N5 -->|"interacts with"| N0
    N6["DNA"]
    N6 -->|"interacts with"| N0
    N7["GABRB2"]
    N7 -->|"phosphorylates"| N0
    N8["MAPT"]
    N0 -->|"interacts with"| N8
    N9["PSEN1"]
    N0 -->|"interacts with"| N9
    N10["SCARB2"]
    N0 -->|"interacts with"| N10
    N11["TFAM"]
    N0 -->|"interacts with"| N11
    N12["TREM2"]
    N0 -->|"interacts with"| N12
    N13["UCHL1"]
    N0 -->|"interacts with"| N13
    N14["NDUFV1"]
    N0 -->|"phosphorylates"| N14
    N15["neurodegeneration"]
    N0 -->|"implicated in"| N15

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene
    class N10 gene
    class N11 gene
    class N12 gene
    class N13 gene
    class N14 gene

Outgoing (7)

TargetRelationTypeStr
MAPTinteracts_withgene0.60
PSEN1interacts_withgene0.60
SCARB2interacts_withgene0.60
TFAMinteracts_withgene0.60
TREM2interacts_withgene0.60

Incoming (7)

SourceRelationTypeStr
DNAinteracts_withgene0.60
A2Minteracts_withgene0.60
BCHEinteracts_withgene0.60
CHRFAM7Ainteracts_withgene0.60
CNTN1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABRB3 in their description or question text

No additional research found