| Gene Symbol | CX3CR1 |
| Full Name | CX3C Chemokine Receptor 1 |
| Chromosome | 3p21.31 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | GPCR antagonist modulating microglial activation and neuroinflammation |
| Mechanism of Action | GPCR antagonist modulating microglial activation and neuroinflammation |
| Primary Expression | Microglia, Monocytes, NK cells, T cells |
| Subcellular Localization | </th><td>Plasma membrane, endosomes</td></tr> |
| Druggability | Low (0.44) |
| Clinical Stage | Phase II |
| Pathways | Complement, Immune Response, Neuroinflammatory, Oxidative Stress, Synaptic Plasticity |
| UniProt ID | P41597 |
| NCBI Gene ID | 1524 |
| Ensembl ID | ENSG00000168329 |
| OMIM | 601470 |
| GeneCards | CX3CR1 |
| Human Protein Atlas | CX3CR1 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | Baicalein |
| Interactions | AD, AGING, AIF1, AKT, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Optogenetic Microglial Deactivation via Engineered CX3CR1 Promoter Methylation Disrupts Neuron-Microg CX3CR1 Agonism Enhances Microglial Phagocytosis of (+2 more) |
| KG Connections | 1292 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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