| Gene Symbol | CLDN5PROTEIN |
| Full Name | Claudin-5 Protein |
| Protein Family | Claudin family |
| Target Class | Structural Protein |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Tight junction protein modulation - no established druggable mechanisms |
| Druggability | Undruggable (0.20) |
| Clinical Stage | Approved |
| Molecular Weight | 21.8 kDa |
| UniProt ID | O00511 |
| GeneCards | CLDN5PROTEIN |
| Human Protein Atlas | CLDN5PROTEIN |
| Two extracellular loops | The first extracellular loop determines charge selectivity |
| Cytoplasmic N- and C-termini | The C-terminus interacts with PDZ domain proteins including ZO-1, ZO-2, and ZO-3 |
| Associated Diseases | ALS, blood-retinal barrier integrity, Brain Edema, neurodegeneration, stroke |
| Known Drugs/Compounds | curcumin, resveratrol |
| Interactions | ABCB1, ABCD1, ABCD2, ABCG2, AMYLOID, AND |
| SciDEX Target | View Target Profile (5 clinical trials) |
| SciDEX Hypotheses | Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Plasma Claudin-5 Proteolytic Fragments Distinguish Vascular-Glial Interface Restoration (+2 more) |
| KG Connections | 394 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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