Contents

CaMKII Protein (CaMK2A)

🔬 Protein Info

Gene Symbol	CAMK2A
Full Name	Calcium/Calmodulin-Dependent Protein Kinase II Alpha
Protein Type	Serine/Threonine Kinase
Function	Calcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory
Molecular Weight	54.1 kDa (monomer)
Pathways	Hepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation
UniProt ID	[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
GeneCards	CAMK2A
Human Protein Atlas	CAMK2A
Kinase domain	Catalytic domain with ATP and substrate binding sites
Regulatory segment	Contains autoinhibitory region and calmodulin-binding domain
Variable linker	Provides flexibility for hub assembly
Association domain (hub)	Mediates dodecameric assembly
12-14 subunits	Assemble into wheel-like structure
Subunit exchange	Active subunits can transactivate other holoenzymes
Associated Diseases	Als, epilepsy, Ms, neuroscience
Known Drugs/Compounds	Cytosolic Calcium
Interactions	AND, ARC, ATM, BDNF, BRCA1, BRD4
SciDEX Hypotheses	CaMKII-Dependent Synaptic Circuit Amplification
KG Connections	148 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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