concept

MMP10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MMP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

22Outgoing

14Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MMP10
Key Genes/Proteins	DEPRESSION, EZH2, MAPK, MICROGLIA
Related Diseases	Depression, Inflammation, neuroinflammation
Related Pathways	Epigenetic, H2AK119ub, H3K27me3, Histone Modification, Mapk

Pathway Diagram

graph TD
    MMP10["MMP10"]
    MMP10 -->|"activates"| NF__B_MAPK_Pathway["NF-kappaB/MAPK Pathway"]
    MMP10 -->|"mediates"| Neuroinflammation["Neuroinflammation"]
    MMP10 -->|"activates"| Depression["Depression"]
    MMP10 -->|"activates"| Inflammation["Inflammation"]
    MMP10 -->|"activates"| Mapk["Mapk"]
    MMP10 -->|"regulates"| Epigenetic["Epigenetic"]
    MMP10 -->|"activates"| Nf__b["Nf-Kappab"]
    PCGF1["PCGF1"] -->|"inhibits"| MMP10
    RING1B["RING1B"] -->|"regulates"| MMP10
    EZH2["EZH2"] -->|"regulates"| MMP10
    H2AK119ub["H2AK119ub"] -->|"regulates"| MMP10
    H3K27me3["H3K27me3"] -->|"regulates"| MMP10
    DEPRESSION["DEPRESSION"] -->|"activates"| MMP10

Outgoing (22)

Target	Relation	Type	Str
NF-κB/MAPK Pathway	activates	pathway	0.88
Neuroinflammation	mediates	process	0.85
Depression	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
MICROGLIA	activates	gene	0.60
Mapk	activates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Histone Modification	regulates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	regulates	cell_type	0.60
RING1B	activates	gene	0.60
neuroinflammation	activates	disease	0.60
microglia	expressed_in	cell_type	0.60
MAPK signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
DEPRESSION	activates	gene	0.60
PCGF1	activates	gene	0.60
SYNAPSE	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (14)

Source	Relation	Type	Str
PCGF1	inhibits	gene	0.95
PCGF1	downregulates	gene	0.94
RING1B	regulates	protein	0.90
EZH2	regulates	protein	0.90
H2AK119ub	regulates	mechanism	0.85
H3K27me3	regulates	mechanism	0.85
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
MAPK	activates	gene	0.60
EZH2	activates	gene	0.60
DEPRESSION	activates	gene	0.60
PCGF1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
SYNAPSE	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MMP10 in their description or question text

No additional research found