mechanism 1,807 words KG: ent-gene-c9882297
Contents

MS4A4A-MS4A6A Cooperation in TREM2 Regulation

🔬 Protein Info
Gene SymbolMS4A4A
Full NameMS4A6A Cooperation in TREM2 Regulation
AliasesMembrane-Spanning 4-Domains A4A
Chromosome11q12.2
Functionencodes a membrane protein expressed primarily in immune cells, particularly microglia and other myeloid cells.
Primary Expressionimmune cells, particularly microglia and other myeloid cells
Molecular Weight24 kDa
Amino Acids199 aa
Exons6
UniProt IDQ9H3Y1
NCBI Gene ID246213
Ensembl IDENSG00000166926
OMIM614508
GeneCardsMS4A4A
Human Protein AtlasMS4A4A
Associated DiseasesAlzheimer's disease, Cancer
InteractionsAND, APOE, CLU, CR1, MS4A, MS4A6A
KG Connections54 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Wikipedia

Related Hypotheses (22)

TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
← Prevpg 2/2

Related Analyses (30)

Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived
What are the optimal timing windows for TREM2 agonism vs ant
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (6)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (7)

sTREM2 (Soluble TREM2) - Microglial Biomarker
biomarker · Pages share 3 hypotheses
sTREM2 (Soluble TREM2) - Biomarker
biomarker · Pages share 3 hypotheses
al002-trem2-agonist-alzheimers
clinical_trial · Pages share 3 hypotheses
TREM2 Gene
gene · Pages share 3 hypotheses
TREM2 in Amyotrophic Lateral Sclerosis
mechanism · Pages share 3 hypotheses

Knowledge Graph (2 edges)

ent-gene-c9882297 data_in benchmark_ot_ad_answer_key:MS4A4A
benchmark_ot_ad_answer_key:MS4A4A data_in ent-gene-c9882297

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