biomarker 1,043 words KG: sTREM2
Contents

sTREM2 (Soluble TREM2) - Microglial Biomarker

🔬 Protein Info
Gene SymbolsTREM2
Microglial Activation MarkersTREM2 reflects TREM2-expressing microglia
Functional ImplicationsMay have both protective and pathogenic roles
Disease Stage EffectsLevels vary across AD disease progression
Increased in ADElevated compared to healthy controls
MCI StageIncreases in prodromal AD
Disease ProgressionCorrelates with clinical decline
Plaque PathologyAssociated with amyloid plaque burden
Associated DiseasesAlzheimer's Disease, Early AD
KG Connections20 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

Wikipedia

Related Hypotheses (14)

Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (13)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (6)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

sTREM2 (Soluble TREM2) - Biomarker
biomarker · Pages share 4 hypotheses
trem2-alpha-synuclein-clearance-parkinsons
general · Pages share 4 hypotheses
TREM2-Deficient Microglia
cell · Pages share 4 hypotheses
TREM2-Expressing Microglia
cell · Pages share 4 hypotheses
TREM2 — Triggering Receptor Expressed on Myeloid Cells
gene · Pages share 4 hypotheses

Knowledge Graph (12 edges)

sTREM2 biomarker_for Microglial Activation
sTREM2 involved_in Proteolytic Shedding
sTREM2 biomarker_for Neurodegenerative Disease
39817909 propagates sTREM2
39748415 did not show significant mediation effects on sTREM2
38001539 mediating sTREM2
38001539 is mediating sTREM2
38001539 mediates sTREM2
sTREM2 biomarker_for Alzheimer's Disease
sTREM2 biomarker_for Alzheimer's disease

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.