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mechanism 3,018 words KG: lysosomal dysfunction
Contents

Lysosomal Dysfunction in Progressive Supranuclear Palsy

⚙ Mechanism Info
Namelysosomal dysfunction
Key Genes/Proteinsamyloid-beta, AMYOTROPHIC LATERAL SCLEROSIS, APOE4, AR, C3, C9orf72
Related DiseasesALS, Alzheimer's disease, amyotrophic lateral sclerosis, carcinoma
Related Pathwaysautophagy pathway, Aβ accumulation
Linked Hypotheses2 hypotheses

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Wikipedia

Related Hypotheses (17)

Circadian-Synchronized Proteostasis Enhancement
Score: 0.74Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67APOE-Dependent Autophagy Restoration
Score: 0.88Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Lysosomal Enzyme Trafficking Correction
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67Complement C1q Subtype Switching
Score: 0.66The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62Lysosomal Membrane Repair Enhancement
Score: 0.54Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60

Related Analyses (30)

Does TFEB dysfunction cause neurodegeneration or represent a
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (29)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40Viral and Post-Infectious Mechanisms in ALS — Experiment Des
clinical · proposed · Score: 0.40Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (11)

GBA (Redirect)
redirect · KG edge: regulatesAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activatesc9orf72-als-ftd-phenotype-mechanism
general · KG edge: inhibitsDNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: associated_withGRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: causes

Knowledge Graph (12 edges)

TREM2 p.Q33X mutation causes lysosomal dysfunction
lysosomal dysfunction associated_with carcinoma
TDP-43 activates lysosomal dysfunction
GRN causes lysosomal dysfunction
MAPT causes lysosomal dysfunction
C9orf72 causes lysosomal dysfunction
TBK1 prevents lysosomal dysfunction
C3 activates lysosomal dysfunction
RAC1 activates lysosomal dysfunction
TFEB activates lysosomal dysfunction

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