| Gene Symbol | ent-gene-257405c9 |
| Genomic instability | Accumulated DNA lesions in aging neuronssliter2018 2018, cGAS and STING regulate DNA damage-induced aging |
| Mitochondrial DNA leakage | mtDNA escapes to cytosolbanerjee2023 2023, Mitochondrial DNA sensing in neurodegeneration |
| Nuclear pore dysfunction | Permits cytoplasmic DNA accumulationwang2017 2017, cGAS is essential for cellular senescence |
| Telomere erosion | Senescent cells release chromosomal fragmentswang2017 2017, cGAS is essential for cellular senescence |
| MX2 | Promotes tau phosphorylationmathavarajan2024 2024, STING inhibition reduces neuroinflammation in AD models |
| IFITM3 | Enhances Aβ productionwang2024 2024, cGAS inhibitor RU.521 reduces pathological tau-induced inflammation |
| GBP proteins | Disrupt membrane integrityvan2022 2022, Targeting the cGAS-STING pathway for neuroprotection |
| C-176 | Covalently modifies STING |
| H-151 | Blocks STING palmitoylation |
| CoX-2 inhibitors | Downstream suppression |
| RU.521 | cGAS inhibitor |
| Compound 3 | Selective cGAS antagonist |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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