| Gene Symbol | ent-gene-257405c9 |
| H-151 | Covalent modification of STING Cys147, preventing cGAMP binding and palmitoylation[@haag2018] |
| C-176 and derivatives | Covalent modification of STING Cys212, blocking activation[@bang2019] |
| AST-008 | Oral small molecule STING inhibitor in clinical trials[@merrick2020] |
| cGAS/STING activation in AD | Aβ plaques and tau pathology activate cGAS, leading to chronic IFN-β production |
| H-151 treatment | Reduces microglial type I interferon responses, improves synaptic plasticity, and enhances cognitive function in 5xFAD mice |
| Genetic deletion | STING-knockout mice show reduced neuroinflammation and improved memory |
| STING inhibition | H-151 reduces dopaminergic neuron loss and improves motor function in MPTP and α-synuclein mouse models |
| Microglial phenotype | STING blockade shifts microglia from a pro-inflammatory (MGnD) to a homeostatic phenotype |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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