| Gene Symbol | INPP5D |
| Full Name | Inositol Polyphosphate-5-Phosphatase D (SHIP1) |
| Aliases | SHIP1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | hematopoietic cells and microglia |
| Molecular Weight | 145 kDa |
| Amino Acids | 1190 aa |
| Exons | 13 |
| Pathways | PI3K, mTOR, mtor, NF-κB |
| Ensembl ID | ENSG00000168918 |
| GeneCards | INPP5D |
| Human Protein Atlas | INPP5D |
| C2 domain | Mediates calcium-dependent membrane binding, facilitating SHIP1 localization to PI(3,4,5)P3-enriched membrane domains. |
| Substrate | Converts PI(3,4,5)P3 to PI(3,4)P2 through 5'-dephosphorylation |
| Signaling output | Reduces AKT activation, dampening cell survival, proliferation, and inflammatory signaling |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, cancer |
| Interactions | ABCA7, Actin, AD RISK GENES, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE |
| SciDEX Hypotheses | INPP5D (SHIP1) Inhibition to Shift Microglial Pola |
| KG Connections | 364 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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