protein

IL-1Α

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1Α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

1Analyses

18Outgoing

7Incoming

0Experiments

1Debates

Summary

Interleukin-1 alpha (IL-1α) — a pro-inflammatory alarmin cytokine driving neuroinflammation in Alzheimer's and Parkinson's disease via IL-1R1 signaling.

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🔬 Protein Info

Gene Symbol	IL
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["IL-1Alpha"]
    N1["A1 Astrocytes"]
    N0 -->|"associated with"| N1
    N2["Reactive Astrocytes"]
    N0 -->|"activates"| N2
    N3["A1 Reactive Astrocytes"]
    N0 -->|"associated with"| N3
    N4["aging"]
    N0 -->|"activates"| N4
    N5["Astrocytes"]
    N0 -->|"activates"| N5
    N6["TNF-alpha"]
    N0 -->|"activates"| N6
    N7["Astrocyte"]
    N0 -->|"activates"| N7
    N8["Neuroinflammatory"]
    N0 -->|"activates"| N8
    N9["IL-1Beta"]
    N0 -->|"activates"| N9
    N10["Cortex"]
    N0 -->|"activates"| N10
    N11["Hippocampus"]
    N0 -->|"activates"| N11
    N12["FRONTAL"]
    N0 -->|"activates"| N12
    N13["CD68"]
    N0 -->|"activates"| N13
    N14["Neuroinflammation"]
    N14 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N8 pathway
    class N9 protein
    class N13 protein

Outgoing (18)

Target	Relation	Type	Str
Reactive Astrocytes	activates	cell_type	0.95
A1 Astrocytes	associated_with	phenotype	0.95
A1 Reactive Astrocytes	associated_with	phenotype	0.95
ASTROCYTE_ACTIVATION	activates	phenotype	0.90
neuroinflammation	causes	phenotype	0.90
A1 reactive astrocytes	activates	cell_type	0.90
A1 astrocytes	activates	cell_type	0.70
A1 reactive astrocyte	activates	cell_type	0.70
aging	activates	phenotype	0.50
Astrocytes	activates	cell_type	0.50
TNF-α	activates	concept	0.50
Astrocyte	activates	cell_type	0.50
Neuroinflammatory	activates	pathway	0.50
IL-1Β	activates	protein	0.50
Cortex	activates	brain_region	0.50
Hippocampus	activates	entity	0.50
FRONTAL	activates	concept	0.50
CD68	activates	protein	0.50

Incoming (7)

Source	Relation	Type	Str
microglia	produces	cell_type	0.80
SalA	suppresses	gene	0.70
ocular hypertension	activates	disease	0.70
Neuroinflammation	activates	process	0.50
microglia	activates	cell_type	0.50
CX3CR1	activates	gene	0.50
RAGE	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.729

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning IL-1Α in their description or question text

No additional research found