| Gene Symbol | HDAC11 |
| Aliases | Histone Deacetylase 11 |
| Chromosome | 3p25.2 |
| Protein Type | Gene |
| Function | encodes a protein of 347 amino acids with a molecular weight of approximately 39 kDa, making it the smallest mammalian HDAC. |
| Primary Expression | various brain regions including the cerebral cortex, hippocampus, cerebellum, and basal ganglia, with particular enrichment in neurons and, to a lesse |
| Molecular Weight | 39 kDa |
| Amino Acids | 347 aa |
| Exons | 13 |
| Pathways | NF-κB |
| GeneCards | HDAC11 |
| Human Protein Atlas | HDAC11 |
| Promoter region | Contains multiple transcription factor binding sites including Sp1, NF-κB, and STAT motifs |
| Exon structure | 13 exons of variable length, with exons 1-4 encoding the catalytic domain |
| Alternative splicing | Limited evidence for alternative splicing; the major isoform is the full-length protein |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | HDAC3, HDAC5, HDAC7 |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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