gene 718 words KG: XRCC1
Contents

XRCC1 Gene

🧬 Gene Info
Gene SymbolXRCC1
Protein TypeScaffold Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionall tissues: - High expression in brain (neurons, glia) - Moderate expression in other proliferating cells - Induced by oxidative stress - Cell type-s
Molecular Weight69 kDa
Amino Acids633 aa
Pathwaysepigenetic regulation, neurotrophin signaling
GeneCardsXRCC1
Human Protein AtlasXRCC1
Associated DiseasesCancer, Fibrosis
InteractionsALDH1A3, App, BDNF, CAMK2A, CANCER, DNA
KG Connections57 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
PARP1 Inhibition Therapy
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68

Related Analyses (7)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40

See Also (12)

DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
Genes
index · KG edge: causes
ALDH1A3 — Aldehyde Dehydrogenase 1 Family Member A3
gene · KG edge: activates
CYP2D6 — Cytochrome P450 2D6
gene · KG edge: causes
FEN1 — Flap Endonuclease 1
gene · KG edge: activates

Knowledge Graph (12 edges)

XPG activates XRCC1
SETX activates XRCC1
TDP1 activates XRCC1
PNKP activates XRCC1
FEN1 activates XRCC1
XPF activates XRCC1
XRCC1 activates SETX
XRCC1 activates FEN1
XRCC1 causes TP53
XRCC1 causes CYP2D6

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