| Gene Symbol | UBA1 |
| Aliases | E1 Ubiquitin-Activating Enzyme |
| Function | Adenylation: UBA1 binds ATP and ubiquitin, forming a ubiquitin-adenylate intermediate |
| Molecular Weight | 117 kDa |
| Amino Acids | 058 aa |
| Pathways | NF-κB |
| Ensembl ID | ENSG00000130985 |
| GeneCards | UBA1 |
| Human Protein Atlas | UBA1 |
| Proteasomal degradation | Polyubiquitin chains (K48-linked) target proteins for 26S proteasome degradation |
| DNA damage response | Monoubiquitination of PCNA and histones regulates repair |
| [NF-κB](/entities/nf-kb) signaling | Linear and K63-linked ubiquitin chains activate NF-κB |
| Endosomal sorting | Ubiquitin signals endosomal trafficking via ESCRT pathway |
| Cell cycle regulation | Ubiquitin-dependent degradation of cyclins and cell cycle inhibitors |
| UBA1a (117 kDa) | Full-length, nuclear-localized; initiates from Met1 |
| Associated Diseases | Senescence |
| Interactions | AGING, INFLAMMATION, NLRP3, PARK2, PINK1, PRKN |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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