gene 2,144 words KG: SUST
Contents

SUMF1 - Sulfatase Modifying Factor 1

🧬 Gene Info
Gene SymbolSUMF1
Full NameSulfatase Modifying Factor 1
AliasesPage for SUMF1 Protein
Chromosome2q33.1
FunctionThe SUMF1 protein, also known as formylglycine-generating enzyme (FGE), catalyzes the conversion of a conserved cysteine residue to formylglycine (FGly) in the active site of all sulfatases.
Primary ExpressionBrain, Liver, Kidney, Lung
Molecular Weight42 kDa
Amino Acids345 aa
Exons9
Pathwaysoxidative stress response
UniProt IDQ8IWU6
NCBI Gene ID285362
Ensembl IDENSG00000144455
OMIM272300
GeneCardsSUMF1
Human Protein AtlasSUMF1
Associated DiseasesMultiple Sulfatase Deficiency
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (160)

Arginine Methylation Enhancement Therapy
Score: 0.65
Microbial Inflammasome Priming Prevention
Score: 0.65
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
Nucleolar Stress Response Normalization
Score: 0.65
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Oligodendrocyte White Matter Vulnerability
Score: 0.65
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Glial Glycocalyx Remodeling Therapy
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
Multi-Modal CRISPR Platform for Simultaneous Editing and Mon
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
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Related Analyses (27)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
MAP2K1 Gene
gene · KG edge: associated_with
MET - MET Proto-Oncogene, Receptor Tyrosine Kinase
gene · KG edge: associated_with
RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-
gene · KG edge: associated_with
TP53 Gene
gene · KG edge: associated_with

Knowledge Graph (8 edges)

SUST associated_with TP53
SUST associated_with MET
SUST associated_with MAP2K1
SUST associated_with RAF1
SUST associated_with GPR91
SUST associated_with PP2C
SUST associated_with HGF
SUST associated_with LZTR1

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