gene 2,144 words KG: SUST
Contents

SUMF1 - Sulfatase Modifying Factor 1

🧬 Gene Info
Gene SymbolSUMF1
Full NameSulfatase Modifying Factor 1
AliasesPage for SUMF1 Protein
Chromosome2q33.1
FunctionThe SUMF1 protein, also known as formylglycine-generating enzyme (FGE), catalyzes the conversion of a conserved cysteine residue to formylglycine (FGly) in the active site of all sulfatases.
Primary ExpressionBrain, Liver, Kidney, Lung
Molecular Weight42 kDa
Amino Acids345 aa
Exons9
Pathwaysoxidative stress response
UniProt IDQ8IWU6
NCBI Gene ID285362
Ensembl IDENSG00000144455
OMIM272300
GeneCardsSUMF1
Human Protein AtlasSUMF1
Associated DiseasesMultiple Sulfatase Deficiency
KG Connections22 knowledge graph edges
DatabasesGeneCardsHPASTRING

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NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (160)

TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68
Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
Flotillin-1 Stabilization Compounds
Score: 0.68
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Complement C1q Subtype Switching
Score: 0.66
RNA Granule Nucleation Site Modulation
Score: 0.66
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
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Related Analyses (27)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
MAP2K1 Gene
gene · KG edge: associated_with
MET - MET Proto-Oncogene, Receptor Tyrosine Kinase
gene · KG edge: associated_with
RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-
gene · KG edge: associated_with
TP53 Gene
gene · KG edge: associated_with

Knowledge Graph (8 edges)

SUST associated_with TP53
SUST associated_with MET
SUST associated_with MAP2K1
SUST associated_with RAF1
SUST associated_with GPR91
SUST associated_with PP2C
SUST associated_with HGF
SUST associated_with LZTR1

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