| Gene Symbol | SUFU |
| Full Name | Suppressor of Fused, Hedgehog Pathway Regulator |
| Chromosome | 10q24.32 |
| Function | encodes a 484 amino acid cytoplasmic protein that is the principal negative regulator of the Hedgehog (Hh) signaling pathway in vertebrates. |
| Amino Acids | 484 aa |
| Exons | 12 |
| Ensembl ID | ENSG00000107882 |
| GeneCards | SUFU |
| Human Protein Atlas | SUFU |
| Phosphorylation | PKA phosphorylates SUFU at Ser342/Ser346, stabilizing the protein and enhancing its GLI-binding capacity |
| Ubiquitination | The SPOP–Cullin3 E3 ligase complex ubiquitinates SUFU for proteasomal degradation upon sustained Hedgehog pathway activation, providing a negative feedback loop |
| SUMOylation | SUMO modification of SUFU enhances nuclear retention and repressor function of GLI |
| Dual phosphatase regulation | PP2A and PP4 dephosphorylate SUFU to reduce its stability, allowing graded pathway activation |
| Cortical development | SUFU regulates the balance between neural progenitor expansion and differentiation. Its conditional deletion in cortical progenitors causes over-proliferation and cortical dysplasia |
| Oligodendrocyte differentiation | SUFU modulates the timing of oligodendrocyte precursor cell (OPC) differentiation by controlling GLI-dependent transcription of proliferation and differentiation genes |
| Associated Diseases | neurodegeneration |
| Interactions | GENES, LZTR1, NF2, SMARCB1 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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