| Gene Symbol | SETD2 |
| H3K36 Trimethylation | Catalyzes H3K36me3, a mark of transcriptionally active genes — this is the primary and most well-characterized function of SETD2 |
| Transcriptional Elongation | Facilitates RNA polymerase II processivity through interaction with the Pol II C-terminal domain |
| RNA Splicing | Regulates alternative splicing through interaction with splicing factors |
| DNA Repair | Involved in mismatch repair and homologous recombination |
| SET Domain | The catalytic methyltransferase domain (~130 amino acids) |
| AWS Domain | Associated with SET domain, required for methyltransferase activity |
| SRI Domain | Set2-Rpb1 Interacting domain that binds to RNA polymerase II CTD phosphorylated at Ser2 |
| Pre-SET Region | Required for proper folding and catalytic activity |
| Associated Diseases | LADC |
| KG Connections | 12 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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