| Gene Symbol | RPL5 |
| Full Name | Ribosomal Protein L5 |
| Chromosome | 1p22.1 |
| Function | RPL5 is a ribosomal protein component of the 60S large ribosomal subunit. |
| Amino Acids | 297 aa |
| Pathways | ubiquitin-proteasome |
| UniProt ID | P46777 |
| NCBI Gene ID | 6125 |
| Ensembl ID | ENSG00000122406 |
| OMIM | 603634 |
| GeneCards | RPL5 |
| Human Protein Atlas | RPL5 |
| Protein synthesis | As part of the 60S subunit, RPL5 participates in the peptidyl transferase activity during protein translation |
| Ribosome assembly | RPL5 is essential for the proper assembly and maturation of the 60S ribosomal subunit |
| MDM2-p53 interaction | RPL5 binds to MDM2 and inhibits MDM2-mediated p53 ubiquitination, thereby stabilizing p53 and activating tumor suppressor pathways |
| Associated Diseases | neurodegeneration |
| Interactions | MDM2, NPM1, RPL11 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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