gene 2,231 words KG: RNF5
Contents

RNF5 — RING Finger Protein 5

🧬 Gene Info
Gene SymbolRNF5
Full NameRING Finger Protein 5
Chromosome6p21.33
Protein FamilyRING finger E3 ubiquitin ligase family
Protein TypeLigase
Functionis a RING-type E3 ubiquitin ligase localized primarily to the endoplasmic reticulum (ER) membrane.
Primary Expressionvirtually all human tissues with highest levels in: - Brain: Cerebral cortex, hippocampus, substantia nigra, cerebellum - Heart: Myocardium, c
Amino Acids180 aa
Exons4
PathwaysImmune Response
UniProt ID[Q99969](https://www.uniprot.org/uniprot/Q99969)
Ensembl IDENSG00000243156
OMIM603419
GeneCardsRNF5
Human Protein AtlasRNF5
Associated Diseasesneurodegeneration
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Related Hypotheses (5)

Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.72
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
PINK1 (PTEN-Induced Kinase 1)
entity · KG edge: therapeutic_target
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: contributes_to
BRCA1 Gene
gene · KG edge: regulates
CFTR Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

MAVS contributes_to RNF5
RNF5 contributes_to NBR1
RNF5 regulates BRCA1
RNF5 regulates CFTR
RNF5 associated_with UBIQUITIN
PINK1 therapeutic_target RNF5
DOCK2 therapeutic_target RNF5
LRPPRC therapeutic_target RNF5
HERC5 expressed_in RNF5
UBIQUITIN expressed_in RNF5

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