gene 662 words KG: PPP2R2A
Contents

PPP2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha

🧬 Gene Info
Gene SymbolPPP2R2A
Full NameProtein Phosphatase 2 Regulatory Subunit B55 Alpha
Chromosome8p21.2
Functionis a hallmark of Alzheimer's disease and other neurodegenerative disorders, making it a critical therapeutic target [2](https://doi.
Molecular Weight52 kDa
Amino Acids447 aa
PathwaysMapk
UniProt IDP63151
NCBI Gene ID5520
Ensembl IDENSG00000156535
OMIM601728
GeneCardsPPP2R2A
Human Protein AtlasPPP2R2A
Associated Diseasesneurodegeneration
InteractionsCANCER, CAV2, ERK, PIK3C3
KG Connections13 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: inhibits
CAV2
gene · KG edge: activates
PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subuni
gene · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

PPP2R2A activates CAV2
PPP2R2A activates PIK3C3
PP2A regulates PPP2R2A
AGING regulates PPP2R2A
PPP2R2A regulates CANCER
PPP2R2A activates Als
PPP2R2A regulates Aging
PPP2R2A regulates Cancer
PPP2R2A activates Mapk
ERK inhibits PPP2R2A

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