gene

NDUFV1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFV1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

0Analyses

8Outgoing

6Incoming

0Experiments

0Debates

Summary

NDUFV1 Gene

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🧬 Gene Info

Gene Symbol	NDUFV1
Full Name	NADH:Ubiquinone Oxidoreductase Core Subunit V1
Chromosome	11q13.2
Protein Type	Oxidoreductase
Function	encodes a core subunit of mitochondrial complex I (NADH:ubiquinone oxidoreductase).
Primary Expression	brain tissue:
UniProt ID	[P22415](https://www.uniprot.org/uniprot/P22415)
Ensembl ID	ENSG00000167792
GeneCards	NDUFV1
Human Protein Atlas	NDUFV1
Mitochondrial complex I deficiency	Well-documented in PD substantia nigra
Oxidative stress	Increased reactive oxygen species
PINK1/PARKIN pathway	Mitophagy defects compound the problem
Mitochondrial dysfunction	Early event in AD pathogenesis
Energy deficit	Reduced ATP production
Associated Diseases	neurodegeneration
Interactions	GABRB2, GABRB3
SciDEX Hypotheses	Mitochondrial Dysfunction in Neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NDUFV1 Gene

gene · 561 words

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Pathway Diagram

graph TD
    NDUFV1["NDUFV1"]
    Als{"Als"}
    NDUFV1 -->|"therapeutic target"| Als
    MAPK14["MAPK14"]
    NDUFV1 -->|"therapeutic target"| MAPK14
    PLEC["PLEC"]
    NDUFV1 -->|"therapeutic target"| PLEC
    CRYAB["CRYAB"]
    NDUFV1 -->|"therapeutic target"| CRYAB
    CASP3["CASP3"]
    NDUFV1 -->|"therapeutic target"| CASP3
    Mapk(["Mapk"])
    NDUFV1 -->|"therapeutic target"| Mapk
    neurodegeneration["neurodegeneration"]
    NDUFV1 -->|"implicated in"| neurodegeneration
    GFAP["GFAP"]
    GFAP -->|"therapeutic target"| NDUFV1
    style NDUFV1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFV1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	therapeutic_target	disease	0.65
Mapk	therapeutic_target	pathway	0.60
MAPK14	therapeutic_target	gene	0.60
PLEC	therapeutic_target	gene	0.60
CRYAB	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:NDUFV1	data_in	dataset_row	0.00
genes-ndufv1	linked_to	wiki	1.00
ds-83b31ef18d49	data_in	dataset	1.00
GFAP	therapeutic_target	gene	0.60
GABRB2	phosphorylates	gene	0.60
GABRB3	phosphorylates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial Dysfunction in Neurodegeneration	0.460	-	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NDUFV1 in their description or question text

No additional research found