gene 2,054 words KG: MS4A6E
Contents

MS4A6E Gene

🧬 Gene Info
Gene SymbolMS4A6E
Full NameMembrane Spanning 4-Domains A6E
Chromosome11q12.2.
Functionis a member of the MS4A gene family located on chromosome 11q12.
Primary Expressionmicroglia, the resident immune cells of the brain, where it plays critical roles in phagocytosis, lipid metabolism, and immun
Molecular Weight25 kDa
Amino Acids253 aa
UniProt IDQ9H3Y5
NCBI Gene ID9315
Ensembl IDENSG00000110079
OMIM606546
GeneCardsMS4A6E
Human Protein AtlasMS4A6E
Associated Diseasesneurodegeneration
InteractionsAPOE, CLU, CR1, MS4A4A, MS4A6A
KG Connections9 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
← Prevpg 2/2

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

Knowledge Graph (9 edges)

APOE interacts_with MS4A6E
CLU interacts_with MS4A6E
CR1 interacts_with MS4A6E
MS4A4A interacts_with MS4A6E
MS4A6A interacts_with MS4A6E
MS4A6E provides_data_for ds-83b31ef18d49
MS4A6E data_in benchmark_ot_ad_answer_key:MS4A6E
benchmark_ot_ad_answer_key:MS4A6E data_in MS4A6E
ds-83b31ef18d49 data_in MS4A6E

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