gene 1,855 words KG: IDUA
Contents

IDUA Gene

🧬 Gene Info
Gene SymbolIDUA
Full NameAlpha-L-iduronidase
Chromosome4p16.3
Protein TypeHydrolase
FunctionHeparan sulfate degradation: IDUA removes iduronic acid residues
Molecular Weight76 kDa
Amino Acids653 aa
UniProt IDP35475
NCBI Gene ID3419
Ensembl IDENSG00000127418
OMIM609014
GeneCardsIDUA
Human Protein AtlasIDUA
Acid-base catalysisResidues in the active site facilitate hydrolysis
Substrate specificityRecognizes the non-reducing end of heparan sulfate and dermatan sulfate
Associated Diseasesneurodegeneration
InteractionsTAU
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (170)

Netrin-1 Gradient Restoration
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TREM2-Mediated Selective Aggregate Clearance Pathway
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Extracellular Vesicle Biogenesis Modulation
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Synaptic Vesicle Tau Capture Inhibition
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HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
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CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57
Astroglial Gap Junction Coordination via Connexin-43 Phospho
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Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53
← Prevpg 8/9Next →

Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: therapeutic_target
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACE therapeutic_target IDUA
TREM2 therapeutic_target IDUA
PILRA therapeutic_target IDUA
IDUA activates TAU
IDUA therapeutic_target GRN
CTSD co_discussed IDUA
IDUA co_discussed INPP5D
IDUA co_discussed NLRP1
IDUA co_discussed SMPD1
INPP5D associated_with IDUA

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