gene 1,855 words KG: IDUA
Contents

IDUA Gene

🧬 Gene Info
Gene SymbolIDUA
Full NameAlpha-L-iduronidase
Chromosome4p16.3
Protein TypeHydrolase
FunctionHeparan sulfate degradation: IDUA removes iduronic acid residues
Molecular Weight76 kDa
Amino Acids653 aa
UniProt IDP35475
NCBI Gene ID3419
Ensembl IDENSG00000127418
OMIM609014
GeneCardsIDUA
Human Protein AtlasIDUA
Acid-base catalysisResidues in the active site facilitate hydrolysis
Substrate specificityRecognizes the non-reducing end of heparan sulfate and dermatan sulfate
Associated Diseasesneurodegeneration
InteractionsTAU
KG Connections31 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (170)

TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Sphingolipid Metabolism Reprogramming
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61
Complement-Mediated Synaptic Pruning Dysregulation
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Correcting Gut Microbial Dopamine Imbalance to Support Syste
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Glycosaminoglycan Template Disruption Approach
Score: 0.60
← Prevpg 7/9Next →

Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: therapeutic_target
GRN Carrier Resilience: Why Some Mutation Carriers Rema
general · KG edge: therapeutic_target
Genes
index · KG edge: associated_with
ACE Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

ACE therapeutic_target IDUA
TREM2 therapeutic_target IDUA
PILRA therapeutic_target IDUA
IDUA activates TAU
IDUA therapeutic_target GRN
CTSD co_discussed IDUA
IDUA co_discussed INPP5D
IDUA co_discussed NLRP1
IDUA co_discussed SMPD1
INPP5D associated_with IDUA

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