gene 549 words KG: GAT1
Contents

GABA Transporter 1

🧬 Gene Info
Gene SymbolGAT1
Full NameGABA Transporter 1
Protein TypeGene
Functionis a sodium-dependent GABA transporter that reuptakes GABA from the synaptic cleft back into presynaptic neurons and surrounding glial cells[@borden1994].
Amino Acids599 aa
Pathwaysoxidative stress response
GeneCardsGAT1
Human Protein AtlasGAT1
Presynaptic neuronsParticularly GABAergic interneurons
[Astrocytes](/entities/astrocytes)Throughout gray matter regions
Axon terminalsEspecially in cortical and hippocampal circuits
Associated DiseasesAls
InteractionsGAT3, IRF3, STING
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (3)

Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Non-Dopaminergic Neurotransmitter Degeneration in PD - Exper
clinical · proposed · Score: 0.40
Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
AQP1 Gene
gene · KG edge: associated_with
CFTR Gene
gene · KG edge: regulates
GABA Transporter 3 (GAT3)
gene · KG edge: activates
IRF3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CFTR regulates GAT1
GAT1 regulates AQP1
GAT1 regulates CFTR
AQP1 associated_with GAT1
CFTR associated_with GAT1
GAT3 activates GAT1
GAT1 activates IRF3
GAT1 activates STING
CFTR transports GAT1
GAT1 transports AQP1

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)