gene

GAT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GAT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	SLC6A11
Full Name	Solute Carrier Family 11 Member 11 (GABA Transporter 3)
Aliases	GAT3
Chromosome	3p25.3
Protein Type	Transporter
Function	is a sodium-dependent GABA transporter belonging to the SLC6A family (neurotransmitter symporters).
Primary Expression	glial cells, particularly astrocytes, where it plays a crucial role in maintaining extracellular and
Amino Acids	583 aa
Gene Type	Protein Coding
UniProt ID	P48066
NCBI Gene ID	6538
Ensembl ID	ENSG00000137914
GeneCards	SLC6A11
Human Protein Atlas	SLC6A11
Associated Diseases	neurodegeneration
Interactions	GAT1, IRF3, STING
KG Connections	4 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GAT3 — AlphaFold P48066 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABA Transporter 3 (GAT3)

gene · 1439 words

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Pathway Diagram

graph TD
    GAT3["GAT3"]
    Ms{"Ms"}
    GAT3 -->|"activates"| Ms
    GAT1["GAT1"]
    GAT3 -->|"activates"| GAT1
    IRF3["IRF3"]
    GAT3 -->|"activates"| IRF3
    STING["STING"]
    GAT3 -->|"activates"| STING
    neurodegeneration["neurodegeneration"]
    GAT3 -->|"implicated in"| neurodegeneration
    style GAT3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	activates	disease	0.65
GAT1	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GAT3 in their description or question text

No additional research found