| Gene Symbol | DICER1 |
| Full Name | Dicer 1, Ribonuclease III |
| Chromosome | 14q32.13 |
| Function | is a fundamental gene encoding an essential endoribonuclease for microRNA (miRNA) biogenesis. |
| Primary Expression | both cytoplasm and nucleus of neurons - Subcellular distribution: Localized to dendritic compartments, enabling local miRNA processing at synapses |
| Molecular Weight | 219 kDa |
| Exons | 25 |
| UniProt ID | [Q9UPY3](https://www.uniprot.org/uniprot/Q9UPY3) |
| Ensembl ID | ENSG00000100697 |
| OMIM | 604310 |
| GeneCards | DICER1 |
| Human Protein Atlas | DICER1 |
| N-terminal DExD/H-box helicase domain | Involved in RNA binding and unwinding |
| DUF283 domain | Platform for protein-protein interactions |
| PAZ domain | Binds the 3' overhang of pre-miRNA substrates |
| Associated Diseases | ALS |
| Interactions | Proteins |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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