gene 1,473 words KG: CAMK4
Contents

CAMK4 — Calcium/Calmodulin-Dependent Kinase 4

🧬 Gene Info
Gene SymbolCAMK4
Full NameCalcium/Calmodulin-Dependent Kinase 4
AliasesGene page for CAMK4
Chromosome5q31.3
Protein TypeKinase
Functionis a serine/threonine protein kinase that plays a critical role in linking calcium signaling to gene transcription in neurons and immune cells.
Primary ExpressionHippocampus, Cerebellum, Thymus, Testis, T-lymphocytes
Subcellular Localizationthe postsynaptic density (PSD) and nucleus, with activity-dependent translocation between these compartments [4](https:/
Molecular Weight63 kDa
Amino Acids519 aa
Exons14
UniProt IDQ16566
NCBI Gene ID814
Ensembl IDENSG00000152495
OMIM114080
GeneCardsCAMK4
Human Protein AtlasCAMK4
Associated DiseasesCancer, Tumor
InteractionsANK3, CANCER, ETV6, GENES, ZBTB20
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (5)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: associated_with
Genes
index · KG edge: activates
CD8 Gene
gene · KG edge: associated_with
SPP1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CAMK4 expressed_in TEX
SPP1 associated_with CAMK4
CD8 associated_with CAMK4
CAMK4 associated_with CD8
CAMK4 associated_with SPP1
CAMK4 therapeutic_target CD8
CAMK4 therapeutic_target SPP1
CAMK4 co_expressed_with CD8
CAMK4 co_expressed_with SPP1
ANK3 activates CAMK4

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