gene 649 words KG: CAMK2G
Contents

CAMK2G — Calcium/Calmodulin-Dependent Kinase 2 Gamma

🧬 Gene Info
Gene SymbolCAMK2G
Full NameCalcium/Calmodulin-Dependent Kinase 2 Gamma
Chromosome10q22.2
Protein TypeSerine/Threonine Kinase
UniProt IDQ13557
NCBI Gene ID817
Ensembl IDENSG00000148660
GeneCardsCAMK2G
Human Protein AtlasCAMK2G
AutophosphorylationCreates calcium-independent activity, a molecular switch for memory [2]
TargetsAMPA receptors, NMDA receptors, transcription factors, cytoskeletal proteins
BrainHippocampus (CA1, CA3, dentate gyrus), cerebral cortex (layers II-VI), cerebellum, basal ganglia
Other tissuesHeart, skeletal muscle, testis, adrenal gland
Cellular localizationPostsynaptic densities, dendritic shafts, nuclear compartments
Dysregulated phosphorylationReduced CaMKII autophosphorylation in AD brains
Associated Diseasesneurodegeneration
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
CEBPA Gene
gene · KG edge: expressed_in
EGR1 Gene
gene · KG edge: associated_with
FOS Gene
gene · KG edge: expressed_in
FOSB Gene
gene · KG edge: expressed_in

Knowledge Graph (8 edges)

FOS expressed_in CAMK2G
MYC associated_with CAMK2G
FOSB expressed_in CAMK2G
CAMK2G associated_with EGR1
CAMK2G expressed_in CEBPA
CAMK2G expressed_in Rb
WT1 expressed_in CAMK2G
ERBB2 expressed_in CAMK2G

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