| Gene Symbol | CASP6PROTEIN |
| Protein Family | Caspase family (C14 clan, executioner caspase) |
| Protein Type | Protease |
| Function | is an executioner cysteine-aspartate protease encoded by the CASP6 gene. |
| Subcellular Localization | Alzheimer's disease tangles, and cleaves [huntingtin](/proteins/huntingtin-prote |
| Molecular Weight | 34 kDa |
| Amino Acids | 293 aa |
| GeneCards | CASP6PROTEIN |
| Human Protein Atlas | CASP6PROTEIN |
| Self-activation capability | Unlike caspase-3/7, procaspase-6 can undergo intramolecular self-cleavage at Asp179, enabling activation without upstream caspases |
| Zinc inhibition site | An allosteric zinc-binding site (His121, Cys163, Cys263) allows physiological regulation by zinc ions |
| Conformational flexibility | The active-site loop (L2') adopts an extended conformation not seen in other executioner caspases, contributing to distinct substrate specificity |
| Associated Diseases | Aging, Alzheimer, Alzheimer Disease, Dementia, Huntington Disease, Pyroptosis |
| Interactions | ALZHEIMER, BCL2A1, CANCER, CASP3, CASP8, CEBPB |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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