| Gene Symbol | C1QC |
| Function | The C1QC gene encodes the C chain of the C1q protein, which is the recognition component of the classical complement pathway. |
| Primary Expression | various tissues, with high expression in: |
| Molecular Weight | 26 kDa |
| Amino Acids | 245 aa |
| Pathways | Complement |
| Ensembl ID | ENSG00000166922 |
| GeneCards | C1QC |
| Human Protein Atlas | C1QC |
| Amyotrophic Lateral Sclerosis | C1q is implicated in the inflammatory response and may be involved in motor neuron degeneration. |
| Age-Related Macular Degeneration | Genetic variants in C1QC are associated with AMD risk. |
| Brain | Local expression by microglia, astrocytes, and neurons. C1q is synthesized in the brain and can be upregulated by inflammatory stimuli. |
| Liver | Primary site of complement protein synthesis |
| Immune cells | Macrophages, monocytes, and dendritic cells |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Interactions | AIF1, APOC1, APOE, C1Q, C1QA, C1QB |
| KG Connections | 217 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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