gene 706 words KG: SIGMA1
Contents

SIGMA1 Gene

🧬 Gene Info
Gene SymbolSIGMA1 (SIGMAR1)
Full NameSigma Non-Opioid Intracellular Receptor 1
Chromosome9p13.3
Protein TypeChaperone
FunctionThe Sigma-1 receptor exhibits diverse biological functions
Primary ExpressionEndoplasmic reticulum, plasma membrane, mitochondria-associated membranes
Molecular Weight25 kDa
Amino Acids223 aa
Gene TypeProtein coding
UniProt IDQ99720
NCBI Gene ID10280
Ensembl IDENSG00000147955
OMIM601978
Associated Diseasesdisease, Neurodegenerative Diseases
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Neurogranin (Ng) - Synaptic Biomarker
biomarker · KG edge: biomarker_for
NeuRon Therapeutics
company · KG edge: expressed_in
Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: biomarker_for
Motor Neuron Disease
redirect · KG edge: associated_with
Neurons
entity · KG edge: associated_with

Knowledge Graph (12 edges)

TREM2 therapeutic_target SIGMA1
SIGMA1 therapeutic_target NEUROGRANIN
SIGMA1 biomarker_for NEUROGRANIN
SIGMA1 biomarker_for TREM2
SIGMA1 therapeutic_target TREM2
NEUROGRANIN therapeutic_target SIGMA1
ALZHEIMER therapeutic_target SIGMA1
SIGMA1 therapeutic_target Alzheimer
SIGMA1 therapeutic_target Neuroinflammation
SIGMA1 therapeutic_target Neuron

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