biomarker 965 words KG: NEUROGRANIN
Contents

Neurogranin (Ng) - Synaptic Biomarker

🔬 Protein Info
Gene SymbolNEUROGRANIN
FunctionNeurogranin is essential for synaptic plasticity through
PathwaysCalcium signaling, Amyloid, Blood-Brain Barrier
GeneCardsNEUROGRANIN
Human Protein AtlasNEUROGRANIN
Cognitive DeclineHigher CSF Ng predicts faster cognitive decline
Synaptic LossCorrelates with synaptic protein loss in AD brain
Disease ProgressionIncreases with disease severity
Diagnostic UtilityHelps differentiate AD from other dementias
Synaptic ProtectionStrategies to preserve synaptic integrity may lower CSF Ng
Drug DevelopmentNg levels used as biomarker in clinical trials
Patient StratificationHigh CSF Ng identifies patients with active synaptic loss
Associated DiseasesAls, Alzheimer, Neuroinflammation
InteractionsBDNF
KG Connections61 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (28)

Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
← Prevpg 2/2

Related Analyses (16)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (7)

Neurofilament Light Chain (NfL) in Blood - Biomarker
biomarker · KG edge: biomarker_for
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: biomarker_for
BACE1 (Redirect)
redirect · KG edge: biomarker_for
GFAP (Redirect)
redirect · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

NFL biomarker_for NEUROGRANIN
BACE1 biomarker_for NEUROGRANIN
SYNAPTOPHYSIN biomarker_for NEUROGRANIN
NEUROGRANIN biomarker_for TAU
NEUROGRANIN biomarker_for SYNAPTOPHYSIN
NEUROGRANIN biomarker_for NFL
NEUROGRANIN biomarker_for BACE1
TREM2 biomarker_for NEUROGRANIN
SIGMA1 therapeutic_target NEUROGRANIN
SIGMA1 biomarker_for NEUROGRANIN

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