| Gene Symbol | MYELIN |
| Chromosome | 18q23 |
| Primary Expression | Oligodendrocytes (CNS), Schwann cells (PNS) |
| Molecular Weight | 18.5-21.5 kDa (various isoforms) |
| Gene | MBP (Myelin Basic Protein), located on chromosome 18q23 |
| Protein | 170-185 amino acids (multiple isoforms via alternative splicing) |
| Exon 2-containing | 21.5 kDa (early development) |
| 17.2 kDa | Most abundant in adult CNS |
| 18.5 kDa | Classic isoform |
| 20.2 kDa | PNN-specific |
| CSF MBP | <4 ng/mL (typically undetectable) |
| Serum MBP | <0.5 ng/mL (very low/undetectable) |
| Multiple Sclerosis | Significant elevation during active demyelination |
| Acute MS relapse | 2-10x baseline |
| Clinically Isolated Syndrome (CIS) | Predictive of conversion to MS |
| Spinal Cord Injury | Very high levels |
| Associated Diseases | ALS, Aging, Als, Alzheimer, Autoimmune |
| KG Connections | 1118 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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