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mechanism 4,656 words KG: amyloid
Contents

amyloid-beta-metalloproteinases

⚙ Mechanism Info
Nameamyloid
Key Genes/ProteinsAPOE, CASP3, CDK5, CLU, CX3CR1, GFAP
Related DiseasesAlzheimer's disease, Alzheimer's Disease, cognitive deficits
Linked Hypotheses44 hypotheses

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Related Hypotheses (36)

Closed-loop optogenetic targeting PV interneurons to restore
Score: 0.95Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.83Exposed amyloidogenic segments (β-sheet propensity residues)
Score: 0.79Test: TREM2 enhances amyloid clearance
Score: 0.76Test: TREM2 enhances amyloid clearance
Score: 0.71Excess orexin-A worsens AD cognition through wake-driven amy
Score: 0.71Test: TREM2 enhances amyloid clearance
Score: 0.70Test: TREM2 enhances amyloid clearance
Score: 0.66Test: TREM2 enhances amyloid clearance
Score: 0.64APOE4-microglial complement signaling causes cholinergic-enr
Score: 0.63Pericyte senescence is sufficient to weaken the BBB even wit
Score: 0.63RNA-binding protein condensate maturation from reversible ph
Score: 0.63RNA-binding protein condensate maturation from reversible ph
Score: 0.63sex-divergent microglial activation states and X-linked immu
Score: 0.63Locus coeruleus degeneration gates whether cholinergic dysfu
Score: 0.62Test: TREM2 enhances amyloid clearance
Score: 0.61Basal forebrain NGF/TrkA trophic failure is an upstream trig
Score: 0.61Closed-loop transcranial focused ultrasound to restore hippo
Score: 0.56Test: TREM2 enhances amyloid clearance
Score: 0.56TREM2-complement-amyloid axis as therapeutic target for prot
Score: 0.55
pg 1/2Next →

Knowledge Graph (12 edges)

GFAP associated_with amyloid
CD33 loss_affects amyloid
amyloid causes cognitive deficits
CX3CR1 co_discussed amyloid
PARP1 co_discussed amyloid
TDP43 co_discussed amyloid
SQSTM1 co_discussed amyloid
CASP3 co_discussed amyloid
CLU co_discussed amyloid
MS4A6A co_discussed amyloid

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