gene 356 words KG: AB
Contents

AB

🧬 Gene Info
Gene SymbolAB
InhibitsACHE (gene)
ActivatesAD (gene), IBA1 (gene)
TargetsAD (gene)
MediatesAUTOPHAGY (pathway), LDLR (gene)
TransportsCHAT (gene)
Associated withEGF (gene), MOG (gene)
Interacts withLDLR (gene), ENDOTHELIAL (cell type)
EnhancesMICROGLIA (cell type)
Co-discussed withACHE, AD, ALZHEIMER'S DISEASE, APOE, AΒ, ENDOTHELIAL
Alzheimer's Diseasevia co_discussed relationship
Multiple Sclerosisvia associated_with relationship
Associated DiseasesMULTIPLE SCLEROSIS
InteractionsACHE, AD, IBA1, LDLR, PDGF, STING
KG Connections53 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (32)

HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA
Score: 0.77
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC
Score: 0.76
miR-33 Antisense Oligonucleotide Hyper-Lipidation Strategy
Score: 0.74
Mutant-dependent amplification is context-dependent and stro
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
H3: APOE4 Impairs Cholesterol Trafficking, Triggering Astroc
Score: 0.72
APOE4-Specific Microglial Metabolic Rescue
Score: 0.71
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
Rab27A/B-mediated exosomal tau secretion from microglia driv
Score: 0.69
A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes
Score: 0.68
APOE4 hypolipidation and ABCA1 mistrafficking impair cholest
Score: 0.68
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Rab12 may better report chronic lysosomal stress biology tha
Score: 0.67
FABP5/7 Inhibition (H2): Lipid Relay Interruption
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66
LDLR Ligand-Binding Domain A Fusion for Receptor-Mediated Tr
Score: 0.65
TREM2-ABI3 actin-phagocytosis coupling is a higher-yield AD
Score: 0.62
CSF Biomarker-Guided ABCA7 Therapeutic Dosing
Score: 0.62
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Knowledge Graph (12 edges)

AB co_discussed MS
AB associated_with MULTIPLE SCLEROSIS
AB associated_with OLIGODENDROCYTE
AB regulates MS
AB associated_with MOG
AB associated_with MS
AB co_discussed ACHE
AB co_discussed RAGE
AB mediates AUTOPHAGY
AB degrades PD

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