The abstract mentions that neuronal loss can exceed 90% in vulnerable populations but doesn't explain the basis for this selective vulnerability. Identifying these protective/risk factors could reveal new therapeutic targets and biomarkers. Gap type: unexplained_observation Source paper: Oxidative stress and neurodegeneration. (2005, Annals of the New York Academy of Sciences, PMID:16037277)
Landscape Summary: What makes certain neuronal populations vulnerable to 90% loss while others are spared in AD? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What makes certain neuronal populations vulnerable to 90% loss while others are spared in AD? — INVOKE-2 (completed)
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