The authors explicitly state this contribution is still debated despite evidence that both glucocorticoids and cytokines inhibit hippocampal neurogenesis. Resolving causality versus correlation is critical for therapeutic targeting. Gap type: open_question Source paper: Depression as a risk factor for Alzheimer's disease: Genes, steroids, cytokines and neurogenesis - What do we need to know? (2016, Frontiers in neuroendocrinology, PMID:26746105)
Landscape Summary: Does diminished neurogenesis contribute to AD onset/progression or merely correlate with disease? is a 0.8 priority gap in neurogenesis. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
Does diminished neurogenesis contribute to AD onset/progression or merely correlate with disease? — INVOKE-2 (completed)
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