The abstract identifies APOE4 association with increased TDP-43 pathology but the mechanistic link is unexplained. This connection could reveal novel therapeutic targets since APOE4 is the strongest genetic risk factor for AD. Gap type: unexplained_observation Source paper: TDP-43 Pathology in Alzheimer's Disease. (2021, Mol Neurodegener, PMID:34930382)
Landscape Summary: How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer's disease? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: partially_addressed.
Colonna, Sevlever, et al. (TREM2 biology)
How does APOE4 mechanistically increase TDP-43 pathology frequency in Alzheimer's disease? — INVOKE-2 (completed)
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