Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about oligomerization: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | regulates | protein | 1.00 |
| TARDBP | involved_in | protein | 0.85 |
| SQSTM1 | involved_in | protein | 0.85 |
| APOE V236E variant | suppresses | protein | 0.80 |
| Apoe3(V236E) | inhibits | variant | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Steric Occlusion of G3BP1 Oligomerization Interface | 0.630 | neurodegeneration | How does TRIM21-mediated K63 ubiquitinat |
| VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding | 0.496 | neurodegeneration | What upstream mechanisms cause TDP-43 to |
| GM1 Ganglioside Reduction via ST3GAL5 Activation to Block Aβ | 0.465 | lipidomics | Lipid metabolism dysregulation in Alzhei |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning oligomerization in their description or question text
No additional research found