Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCFA deficiency: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Microglial dysfunction | drives | Cellular phenotype | 1.00 |
| Enhanced gut permeability | contributes | Pathological state | 1.00 |
| Systemic Inflammation | causes | phenotype | 0.70 |
| microglial dysregulation | causes | process | 0.70 |
| microglial hyperactivation | causes | mechanism | 0.70 |
| pro-inflammatory cytokine production | promotes | mechanism | 0.70 |
| Microglial hyperactivation | causes | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Gut dysbiosis | causes | Pathological state | 1.00 |
| gut dysbiosis | causes | process | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SCFA Deficiency Drives Microglial Hyperactivation via GPR43/ | 0.728 | neurodegeneration | How does gut microbiome dysbiosis contri |
| SCFA Deficiency Disrupts Microglial Homeostasis and Promotes | 0.583 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.728
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630
neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty [PMID:40254847] | Meiying Song, Shanshan Zhang, Yuxin Gan | {'name': 'Journal of agricultu | 2025 | 0 |
| Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short [PMID:41473323] | Vrishali S. Salian, Vaishnavi Veerareddy | {'name': 'bioRxiv'} | 2025 | 0 |
| Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and [PMID:38377788] | Kalyanaraman B, Cheng G, Hardy M | Redox biology | 2024 | 0 |
| Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammatio [PMID:38869276] | Atreye Majumdar, Indira Priya Siva Venka | {'name': 'mBio', 'volume': '15 | 2024 | 0 |
| Rosiglitazone synergizes the neuroprotective effects of valproic acid against qu [PMID:24566814] | Mishra J, Chaudhary T, Kumar A | Neurotox Res | 2014 | 0 |
| Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone d [PMID:17398106] | Sinn DI, Kim SJ, Chu K | Neurobiol Dis | 2007 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.13 · 2026-04-27
closed · Rounds: 4 · Score: 0.76 · 2026-04-26
closed · Rounds: 4 · Score: 0.60 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.82 · 2026-04-22
Hypotheses and analyses mentioning SCFA deficiency in their description or question text
No additional research found