protein

SOD1-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

0Outgoing

1Incoming

0Experiments

0Debates

Summary

SOD1 (Cu/Zn Superoxide Dismutase)

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🔬 Protein Info

Gene Symbol	SOD1
Full Name	PROTEIN
Chromosome	21q22.11
Protein Type	Enzyme
Function	is a copper/zinc-dependent enzyme that catalyzes the dismutation of superoxide radical (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂).
Primary Expression	Motor cortex, Spinal cord, Widespread throughout CNS
Molecular Weight	16 kDa
Amino Acids	154 aa
Pathways	Amyloid, Apoptosis, Autophagy, Epigenetic, Er Stress
Ensembl ID	ENSG00000142168
GeneCards	SOD1
Human Protein Atlas	SOD1
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	Amyloid-Beta Oligomers, antisense oligonucleotides, Antisense Oligonucleotides, ARIMOCLOMOL, CISPLATIN, curcumin
Interactions	ACTB, ACTG1, AD, AGING, AKT, AKT1
KG Connections	2192 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure Comparison — SOD1-PROTEIN Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1SPD — X-ray / Cryo-EM

🔮 AI Predicted Structure

P00441 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    SOD1["SOD1"]
    Vascular_Dementia["Vascular Dementia"]
    SOD1 -->|"interacts_with"| Vascular_Dementia
    HSPB8["HSPB8"]
    SOD1 -->|"activates"| HSPB8
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    SOD1 -->|"regulates"| ALZHEIMER_S_DISEASE
    NFL["NFL"]
    SOD1 -->|"protects_against"| NFL
    Als["Als"]
    SOD1 -->|"expressed_in"| Als
    Microglia["Microglia"]
    SOD1 -->|"activates"| Microglia
    TARDBP["TARDBP"]
    SOD1 -->|"treats"| TARDBP
    MTDNA["MTDNA"]
    SOD1 -->|"activates"| MTDNA
    Atherosclerosis["Atherosclerosis"]
    SOD1 -->|"protects_against"| Atherosclerosis
    TPP1["TPP1"]
    SOD1 -->|"activates"| TPP1
    LAMP2A["LAMP2A"]
    SOD1 -->|"associated_with"| LAMP2A
    CLU["CLU"]
    SOD1 -->|"interacts_with"| CLU
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style Vascular_Dementia fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style HSPB8 fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALZHEIMER_S_DISEASE fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NFL fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Microglia fill:#01579b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TARDBP fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MTDNA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style TPP1 fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style LAMP2A fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CLU fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
entities-dna-methylation	interacts_with	wiki	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SOD1-PROTEIN in their description or question text

No additional research found