concept

STREM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STREM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

4Hypotheses

1Analyses

34Outgoing

3Incoming

0Experiments

2Debates

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💡 Concept Info

Name	STREM2
Key Genes/Proteins	TREM2
Related Diseases	Neural Injury, Neuromyelitis Optica Spectrum Disorders, NMOSD
Related Pathways	Nfkb

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

sTREM2 (Soluble TREM2) - Microglial Biomarker

biomarker · 1043 words

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Pathway Diagram

graph TD
    STREM2["STREM2"]
    STREM2 -.biomarker for.-> Microglial_Activation["Microglial Activation"]
    STREM2 -->|"risk_factor_for"| Neuromyelitis_Optica_Spectrum_["Neuromyelitis Optica Spectrum Disorders"]
    STREM2 -->|"involved_in"| Proteolytic_Shedding["Proteolytic Shedding"]
    STREM2 -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    STREM2 -->|"correlates_with"| Neural_Injury["Neural Injury"]
    STREM2 -.biomarker for.-> Alzheimer_s_Disease["Alzheimer's Disease"]
    STREM2 -->|"upregulates"| Myelin_Debris_Phagocytosis["Myelin Debris Phagocytosis"]
    STREM2 -->|"downregulates"| Lipid_Metabolism["Lipid Metabolism"]

Outgoing (34)

Target	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Microglial Activation	biomarker_for	process	0.93
Neuromyelitis Optica Spectrum Disorders	risk_factor_for	disease	0.92
Neurofilament Light	correlates_with	biomarker	0.92
Total Tau	correlates_with	biomarker	0.92
Phospho-Tau	correlates_with	biomarker	0.92
Plasma	associated_with	biomarker	0.90
Microglia Activity	biomarker_for	process	0.90
Alzheimer's disease	biomarker_for	disease	0.90
TREM2	associated_with	protein	0.90
Cerebrospinal Fluid	associated_with	biomarker	0.90
Early-Stage Alzheimer'S Disease	associated_with	disease	0.90
cerebrospinal fluid	biomarker_for	biofluid	0.90
PLASMA	biomarker_for	biofluid	0.90
Proteolytic Shedding	involved_in	process	0.90
Neuroinflammation	associated_with	process	0.90
Neural Injury	correlates_with	phenotype	0.88
Alzheimer's Disease	biomarker_for	disease	0.88
Neuronal Injury	associated_with	process	0.88
Myelin Debris Phagocytosis	upregulates	process	0.87
Lipid Metabolism	downregulates	process	0.86
Alzheimer'S Disease	biomarker_for	disease	0.85
Nfkb	activates	pathway	0.85
Glycolysis	upregulates	process	0.85
NEUROINFLAMMATION	biomarker_for	process	0.85
Alzheimer'S Disease	therapeutic_target	disease	0.85
microglial dysfunction	triggers	process	0.80
MICROGLIA	triggers_dysfunction	cell_type	0.80
NMOSD	biomarker_for	disease	0.80
Neurodegenerative Disease	biomarker_for	disease	0.80
Neurodegenerative Disease	biomarker_for	disease	0.80
Early AD	associated_with	disease	0.70

Incoming (3)

Source	Relation	Type	Str
TREM2	expressed_in	gene	0.95
TREM2	produces	gene	0.90
Age	upregulates	phenotype	0.88

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind	0.801	neuroimmunology	What is the temporal sequence of TREM2 s
sTREM2 as Biomarker of Cystatin-C Therapeutic Efficacy	0.757	neurodegeneration	View
Integrated Multi-Analyte CSF Panel Combining YKL-40, sTREM2,	0.730	biomarkers	What biomarkers can reliably detect micr
Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha	0.714	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (1)

Scientific analyses that reference this entity

Multi-modal Biomarker Panel Design for Early AD Detection

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage d [PMID:41509917]	Choi C, Lee J, Park G, Namgoong S, Lee Y	iScience	2026	0

Debates (2)

Multi-agent debates referencing this entity

Can a multi-modal biomarker panel combining plasma proteins, neuroimaging featur

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Should clinical practice adopt multi-modal biomarker panels now, or wait for sin

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning STREM2 in their description or question text

No additional research found