entity

Plasma

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Plasma: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections
12Hypotheses
0Analyses
0Outgoing
3Incoming
0Experiments
0Debates

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Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Plasma α-Synuclein Aggregation Seeding Activity as Biomarker — NCT07498686

clinical · 1461 words

ExPlas — Exercise Plasma Transfusion for Alzheimer's Disease (NCT05068830)

clinical · 2839 words

Plasma Biomarkers in Neurodegeneration

diagnostic · 2813 words

Plasmalogen Metabolism in Neurodegeneration

mechanism · 1852 words

Plasma Phospho-Tau Ratio Diagnostic Panel for Alzheimer's Disease

biomarker · 1144 words

Plasma p-tau181 (Phosphorylated Tau at Threonine 181)

biomarker · 1095 words

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (3)

SourceRelationTypeStr
STREM2biomarker_forprotein0.90
IL23Rexpressed_inprotein0.90
Strem2associated_withprotein0.90

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Plasma NfL Elevation Secondary to BBB-Associated Transport D 0.940 - What blood-brain barrier permeability ch
CSF/Plasma AQP4 Polarization Index as a Novel Biomarker of A 0.705 - What blood-brain barrier permeability ch
Plasma Claudin-5 Proteolytic Fragments Distinguish Paracellu 0.705 - What blood-brain barrier permeability ch
Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Sec 0.685 - What blood-brain barrier permeability ch
Neurovascular Permeability Score (NVPS): Composite Plasma + 0.600 - Blood-brain barrier permeability changes
Complement C1q Suppression as Mechanism Linking Exercise Pla 0.560 neurodegeneration What are the specific circulating factor
Plasma NfL Elevation Secondary to BBB-Associated Transport D 0.485 - What blood-brain barrier permeability ch
Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-00 0.323 molecular neurobiology View
plasma LPS-binding protein separates causal from compensator 0.321 neurodegeneration How does gut microbiome dysbiosis contri
plasma GFAP separates causal from compensatory states in: Bl 0.321 neurodegeneration Blood-brain barrier permeability changes
Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining 0.000 biomarkers What biomarkers can reliably detect micr
Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic 0.000 biomarkers What biomarkers can reliably detect micr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] Shi, Sato, Takahashi, Ohno-Ohishi, Muray Life science alliance 2025 0
The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] Karunakaran DKP, Ley M, Guo J, Khatri A, Molecular neurodegeneration 2025 0
AAV2-driven endothelin induces chronic reduced retinal blood flow/retinal gangli [PMID:40345829] Unknown Life science alliance 2025 0
The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegen [PMID:40468412] Karunakaran DKP, Ley M, Guo J, Khatri A, Molecular neurodegeneration 2025 0
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to pro [PMID:40404995] Groh J, Feng R, Yuan X, Liu L, Klein D, Nature neuroscience 2025 0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] Wang W, Wang Y, Wang F, Xie G, Liu S, Li Phytomedicine : international 2024 0
Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] Taheri M, Roghani M, Sedaghat R Cellular and molecular neurobi 2024 0
Sirt6 protects retinal ganglion cells and optic nerve from degeneration during a [PMID:38659223] Xia F, Shi S, Palacios E, Liu W, Buscho Molecular therapy : the journa 2024 0
Metformin Mitigates Trimethyltin-Induced Cognition Impairment and Hippocampal Ne [PMID:39441380] Taheri M, Roghani M, Sedaghat R Cellular and molecular neurobi 2024 0
Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and [PMID:38552431] Wang W, Wang Y, Wang F, Xie G, Liu S, Li Phytomedicine : international 2024 0
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662] ["Zhang Di", "Jing Bei", "Chen Zhen-Ni", CNS neuroscience & therapeutic 2023 0
Dual-targeting of brain tumors with nanovesicles. [PMID:36816997] Kianinejad N, Kwon YM Bioimpacts 2023 0
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081] Park, Hwang, Lee, Jang, Jeong et al. Frontiers in immunology 2023 0
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation [PMID:37435081] Unknown Frontiers in immunology 2023 0
Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting n [PMID:36601662] ["Zhang Di", "Jing Bei", "Chen Zhen-Ni", CNS neuroscience & therapeutic 2023 0
Peripheral inflammation and blood-brain barrier disruption: effects and mechanis [PMID:33381913] Huang X, Hussain B, Chang J CNS Neurosci Ther 2021 0
Early glycolytic reprogramming controls microglial inflammatory activation. [PMID:34107997] ["Cheng Junjie", "Zhang Rong", "Xu Zhiro Journal of neuroinflammation 2021 0
Blood-Brain Barrier Disruption by Lipopolysaccharide and Sepsis-Associated Encep [PMID:34804998] Peng X, Luo Z, He S Front Cell Infect Microbiol 2021 0
Blood-Brain Barrier Overview: Structural and Functional Correlation. [PMID:34912450] Alahmari A Neural Plast 2021 0
Early glycolytic reprogramming controls microglial inflammatory activation. [PMID:34107997] ["Cheng Junjie", "Zhang Rong", "Xu Zhiro Journal of neuroinflammation 2021 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Plasma in their description or question text

Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuro

Score: 0.560 · neurodegeneration · 2026-04-14

## Mechanistic Overview Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection sta

Plasma NfL Elevation Secondary to BBB-Associated Transport Dysfunction Enables L

Score: 0.485 · unknown disease · 2026-04-26

Neurofilament light chain (NfL) is released from damaged neurofilaments into the extracellular space, flowing into CSF a

Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeutic Windo

Score: 0.323 · molecular neurobiology · 2026-04-17

## Mechanistic Overview Plasma p-tau217-Triggered Exosome Dosing Maximizes lncRNA-0021 Therapeutic Window in AD starts f

plasma LPS-binding protein separates causal from compensatory states in: How doe

Score: 0.321 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma LPS-binding protein can distinguish harmful mechanisms from protective

plasma GFAP separates causal from compensatory states in: Blood-brain barrier pe

Score: 0.321 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on plasma GFAP can distinguish harmful mechanisms from protective adaptation. Th

Dynamic Plasma Exosome-Derived Multi-Analyte Panel Combining YKL-40, sTREM2, and

Score: 0.000 · biomarkers · 2026-04-26

This hypothesis proposes that plasma-derived exosomes carrying YKL-40, sTREM2, and neurogranin provide a superior biomar

Plasma TREM2 Ectodomain Glycosylation Pattern as Therapeutic Response Predictor

Score: 0.000 · biomarkers · 2026-04-26

Site-specific glycosylation patterns on circulating TREM2 ectodomain fragments reflect the metabolic state and activatio