Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UBE2I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | UBE2I |
| Full Name | SUMO-Conjugating Enzyme |
| Chromosome | 16p13.3 |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain with high levels in hippocampus, cortex, and basal ganglia |
| Molecular Weight | 18 kDa |
| UniProt ID | [P63279](https://www.uniprot.org/uniprot/P63279) |
| Ensembl ID | ENSG00000184254 |
| OMIM | 601231 |
| GeneCards | UBE2I |
| Human Protein Atlas | UBE2I |
| [Tau](/proteins/tau) | SUMOylation of tau at Lysine 340 promotes tau aggregation and formation of neurofibrillary tangles. HypoSUMOylation of tau may also contribute to toxic gain-of-function [4] |
| [APP](/entities/app-protein) | SUMOylation of amyloid precursor protein influences amyloid-beta production |
| [BACE1](/proteins/bace1) | SUMOylation of beta-secretase modulates its activity and amyloidogenesis |
| Associated Diseases | neurodegeneration |
| Interactions | ATF3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
UBE2I["UBE2I"]
Als{"Als"}
UBE2I -->|"expressed in"| Als
Ms{"Ms"}
UBE2I -->|"expressed in"| Ms
neurodegeneration["neurodegeneration"]
UBE2I -->|"implicated in"| neurodegeneration
TP53["TP53"]
TP53 -->|"expressed in"| UBE2I
UBIQUITIN["UBIQUITIN"]
UBIQUITIN -->|"expressed in"| UBE2I
P53["P53"]
P53 -->|"expressed in"| UBE2I
ATF3["ATF3"]
ATF3 -->|"interacts with"| UBE2I
SENP2["SENP2"]
SENP2 -->|"expressed in"| UBE2I
style UBE2I fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UBE2I in their description or question text
No additional research found